The flu is a contagious, infectious disease that impacts people of all ages and ethnicities 2,3

  • Annually, the flu places a significant burden on the health of the people living in the United States 4
  • Symptoms of the flu arise abruptly, often within as little as 24 hours of infection 5
  • The clinical course of the flu lasts approximately 3 to 14 days 6
  • The flu can be contagious even before symptoms appear, and for up to 5 to 7 days after 5

There are serious risks associated with the flu 8

Millions in the US are at high risk for developing flu complications

For high-risk patients, the dangers of the flu are even greater, leading to serious complications and even death. 10-14

Other risk factors include American Indian and Alaskan Natives ethnicity, residents of long-term care facilities, neurological/neurodevelopmental conditions, pregnant women and women ≤ 2 weeks postpartum, metabolic disorders, extreme obesity (body mass index [BMI] of 40 or greater) and blood disorders such as sickle cell disease.

Because of the variable nature of the flu, many current flu management options are insufficient

  • Despite their availability, flu vaccines are not always used or are not always effective, leaving millions of people at risk
    • Only 45% of adults were vaccinated for the flu based on early estimates from the 2018-2019 flu season 15
    • Vaccine effectiveness has varied from 10%-60% from the 2004-2018 flu seasons 16
  • Antivirals have been shown to shorten flu symptoms 17

Fight the flu with an antiviral

The flu vs the common cold

Because the common cold and the flu share similar symptoms, it can be difficult to distinguish between these two illnesses. Generally, the flu is more severe than the common cold, and so are the symptoms. If not treated in a timely manner, the flu may lead to serious complications such as pneumonia, organ failure, and worsening of chronic medical conditions. So it’s important to recognize the signs and symptoms of the flu when they present. 18


Signs and Symptoms Influenza Cold
Symptom onset Abrupt Gradual
Fever Usual Rare
Aches Usual Slight
Chills Fairly common Uncommon
Fatigue, weakness Usual Sometimes
Sneezing Sometimes Common
Stuffy nose Sometimes Common
Sore throat Sometimes Common
Chest discomfort, cough Common Mild to moderate
Headache Common Rare

*Median time to improvement of symptoms vs placebo (54 hours vs 80 hours in Trial 2; 73 hours vs 102 hours in Trial 3).
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Track the flu in your area

See if the flu is circulating in your area with our Flu Tracker.

Proven results with XOFLUZA

XOFLUZA improved flu symptoms in both otherwise healthy and high-risk flu patients. 1*