Skip To Main Content

The flu is serious. Treat it seriously.

The flu can hit you fast and leave you with debilitating symptoms that last for more than a week. And it’s not just you. The CDC estimates that each year, up to 45 million people will be affected by the flu.* It can also lead to serious complications.

Look out for three common flu symptoms.

XOFLUZA® (baloxavir marboxil)

You don’t have to have all of the symptoms above to have the flu. If you’re experiencing any symptoms, don’t wait for things to get worse—contact your doctor when they first appear.

Is it the flu or COVID-19?

It is difficult to tell the difference between COVID-19 and the flu because some of the symptoms can be similar.

If you have flu-like symptoms, contact a healthcare provider. If it is the flu, you may be able to treat it with prescription XOFLUZA. But keep in mind, XOFLUZA does not treat COVID-19.

Is it a cold or the flu?

It can also be tough to tell the difference between a cold and the flu. But one sign of the flu is the way its symptoms come on fast. Use the chart below to check your symptoms.

If you think you have the flu, talk to your doctor within the first 48 hours of flu symptoms and ask if prescription XOFLUZA is right for you.

Signs and Symptoms Flu Cold
Symptom onset Abrupt Gradual
Fever Usual Rare
Aches Usual Slight
Chills Fairly common Uncommon
Fatigue, weakness Usual Sometimes
Sneezing Sometimes Common
Stuffy nose Sometimes Common
Sore throat Sometimes Common
Chest discomfort, cough Common Mild to moderate
Headache Common Rare

Attack the flu virus at its source with XOFLUZA.

In certain patients who are at risk for complications, the CDC recommends treating the flu with a prescription medication within the first 48 hours of experiencing symptoms.* People with mild illness, who are not at risk for complications, may also be treated early with prescription XOFLUZA.

Over-the-counter medicines just treat symptoms. Prescription XOFLUZA works differently with only one dose. 

*Source: Centers for Disease Control and Prevention (CDC). The CDC does not endorse private products, services, or enterprises. The content provided is for informational purposes only. Find the latest at

Feel better in just over 2 days with XOFLUZA.

 2 Days Icon

On average, patients 12 years of age and older felt better in 2.3 days versus 3.3 days with placebo.

Know when the flu may be spiking in your area.

 Flu Map Icon

Talk to a doctor online now.

 Phone Icon

Don't wait to talk to a doctor and ask about prescription XOFLUZA. Use this virtual care service to book an appointment.  

What is XOFLUZA?

XOFLUZA is a prescription medicine used to:

  • Treat the flu (influenza) in people 12 years of age and older who have had flu symptoms for no more than 48 hours.
  • Prevent the flu in people 12 years of age and older following contact with a person who has the flu.

It is not known if XOFLUZA is safe and effective in children less than 12 years of age.

Important Safety Information

Who should not take XOFLUZA?
Do not take XOFLUZA if you are allergic to baloxavir marboxil or any of the ingredients in XOFLUZA.

What should I tell my healthcare provider before using XOFLUZA?

  • Tell your healthcare provider about all of your medical conditions, including if you are:
    • Pregnant or plan to become pregnant. It is not known if XOFLUZA can harm your unborn baby.
    • Breastfeeding or plan to breastfeed. It is not known if XOFLUZA passes into your breast milk.
  • Tell your healthcare provider about all of the medicines you take, including prescription and over-the-counter medicines, antacids, laxatives, vitamins, and herbal supplements.

What are the possible side effects of XOFLUZA?
Serious side effects may include

  • Allergic reaction. Get emergency medical help right away if you develop any of the following signs or symptoms of an allergic reaction:
    • trouble breathing
    • skin rash, hives or blisters
    • swelling of your face, throat or mouth
    • dizziness or lightheadedness


The most common side effects of XOFLUZA in clinical studies were diarrhea, bronchitis, nausea, sinusitis, and headache. These are not all the possible side effects of XOFLUZA. Call your healthcare provider for medical advice about side effects.

XOFLUZA is not effective in treating or preventing infections other than influenza. Other kinds of infections can have symptoms like those of the flu or occur along with flu and may need different kinds of treatment. XOFLUZA does not prevent bacterial infections that may happen with the flu. Tell your healthcare provider if you feel worse or develop new symptoms during or after treatment with XOFLUZA or if your flu symptoms do not start to get better.

You are encouraged to report side effects to Genentech by calling 1-888-835-2555 or to the FDA by visiting or calling 1-800-FDA-1088.

Please see full Prescribing Information, including Patient Product Information.